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15+ years of monitoring solutions & services


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Currently we are specializing in SCADA protocols and Real-Time middleware (2001-2021)

IndigoSCADA
Telecontrol and monitoring

In the past we have done:

Automated chemical analysis of indigo and sodium hydrosulfite using only optical methods (1996-2008)

Endenim application note

Ceramic tile classification using a small number of image features, with improved machine usability (1998-2000)

Ceramic tiles

Service and data acquisition software for paper machines (1995-1996)

Paper machines

In 1993 we moved from organic chemistry to computer science.

Drug design, in terms of research it is similar to software: partly based on rigor, partly on intuitions.

In 1993 our research group published the article about iminosugars:

Lay L., Nicotra F., Paganini A., Pangrazio C., Panza L.
A new procedure for the synthesis of azasugars
(1993) Tetrahedron Letters, 34 (28), pp. 4555-4558.

A new procedure for the synthesis of azasugars
Documents that cite the paper

Poster published on 28 May 1992
cover (1992)
poster (1992)

May 1991: we were stuck in the synthesis of the molecule 9, when we get the molecule 10 thanks to serendipity.
This research earned us a coffee and thirty years of article citations.
thesis_page23 (1991)
thesis_page24 (1991)
thesis_page50 (1991)
thesis_page56 (1991)
thesis_page57 (1991)
thesis_page58 (1991)



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It seems that now (2020) the route to produce iminosugars is double reductive amination (DRA):

THE DOUBLE REDUCTIVE AMINATION APPROACH TO THE SYNTHESIS OF POLYHYDROXYPIPERIDINES

introduced by Ellen W. Baxter and Allen B. Reitz in 1994

Expeditious Synthesis of Aza sugars by the Double Reductive Amination of Dicarbonyl Sugars



DRA

It is amazing that such a small change replacing an oxygen atom in a sugar molecule with a nitrogen atom can have wide ranging therapeutic benefits.

Iminosugars: small molecules with big potential

Iminosugar antivirals: the therapeutic sweet spot

Repurposing of Miglustat to inhibit the coronavirus Severe Acquired Respiratory Syndrome SARS-CoV-2

The iminosugars celgosivir, castanospermine and UV-4 inhibit SARS-CoV-2 replication

Iminosugars With Endoplasmic Reticulum alpha-Glucosidase Inhibitor Activity Inhibit ZIKV Replication and Reverse Cytopathogenicity in vitro




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