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Iminosugars Section




Contribution to iminosugars field

In 1993 our research group published the article about azasugars (also known as iminosugars):

Lay L., Nicotra F., Paganini A., Pangrazio C., Panza L.
A new procedure for the synthesis of azasugars
(1993) Tetrahedron Letters, 34 (28), pp. 4555-4558.

- A new procedure for the synthesis of azasugars

A new procedure for the synthesis of azasugars
Documents that cite the paper

Poster published on 28 May 1992
cover (1992)
poster (1992)

May 1991: I was stuck in the synthesis of the molecule 9, when I get the molecule 10 thanks to serendipity.
This research earned me a coffee and thirty years of article citations.
thesis_page23 (1991)
thesis_page24 (1991)
thesis_page50 (1991)
thesis_page56 (1991)
thesis_page57 (1991)
thesis_page58 (1991)



Nicotra_approach.png

It seems that now (2020) the route to produce iminosugars is double reductive amination (DRA):

THE DOUBLE REDUCTIVE AMINATION APPROACH TO THE SYNTHESIS OF POLYHYDROXYPIPERIDINES

introduced by Ellen W. Baxter and Allen B. Reitz in 1994

Expeditious Synthesis of Aza sugars by the Double Reductive Amination of Dicarbonyl Sugars



DRA

It is amazing that such a small change replacing an oxygen atom in a sugar molecule with a nitrogen atom can have wide ranging therapeutic benefits.

Iminosugars: small molecules with big potential

Iminosugar antivirals: the therapeutic sweet spot

Repurposing of Miglustat to inhibit the coronavirus Severe Acquired Respiratory Syndrome SARS-CoV-2

The iminosugars celgosivir, castanospermine and UV-4 inhibit SARS-CoV-2 replication

Iminosugars With Endoplasmic Reticulum alpha-Glucosidase Inhibitor Activity Inhibit ZIKV Replication and Reverse Cytopathogenicity in vitro

Sirona Biochem

Tuning the activity of iminosugars




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